This lecture is devoted to the Vita nuova, Dante's autobiographical account of his "double apprenticeship" in poetry and love. The poet's love for Beatrice is explored as the catalyst for his search for a new poetic voice. Medieval theories of love and the diverse poetics they inspired are discussed in contrast. The novelty of the poet's final resolution is tied to the relationship he discovers between love and knowledge.

Professor Mazzotta introduces students to the general scheme and scope of the Divine Comedy and to the life of its author. Various genres to which the poem belongs (romance, epic, vision) are indicated, and special attention is given to its place within the encyclopedic tradition. The poem is then situated historically through an overview of Dante's early poetic and political careers and the circumstances that led to his exile. Professor Mazzotta concludes by discussing the central role Dante's exile was to play in his poetic project.

Professor Kleiner features the baroque phenomenon in Roman architecture, in which the traditional vocabulary of architecture, consisting of columns and other conventional architectural elements, is manipulated to enliven building façades and inject them with dynamic motion. This baroque trend is often conspicuously ornamental and began to be deployed on the walls of forums and tombs in Italy already in the late first century A.D.

The Final Exam covers material from the entire course.

After discussing the statistical basis of the law of mass action, the lecture turns to developing a framework for understanding reaction rates. A potential energy surface that associates energy with polyatomic geometry can be realized physically for a linear, triatomic system, but it is more practical to use collective energies for starting material, transition state, and product, together with Eyring theory, to predict rates. Free-radical chain halogenation provides examples of predicting reaction equilibria and rates from bond dissociation energies.

After discussing the classic determination of the heat of atomization of graphite by Chupka and Inghram, the values of bond dissociation energies, and the utility of average bond energies, the lecture focuses on understanding equilibrium and rate processes through statistical mechanics. The Boltzmann factor favors minimal energy in order to provide the largest number of different arrangements of "bits" of energy. The slippery concept of disorder is illustrated using Couette flow.

Although molecular mechanics is imperfect, it is useful for discussing molecular structure and energy in terms of standard covalent bonds. Analysis of the Cambridge Structural Database shows that predicting bond distances to within 1% required detailed categorization of bond types. Early attempts to predict heats of combustion in terms of composition proved adequate for physiology, but not for chemistry. Group- or bond-additivity schemes are useful for understanding heats of formation, especially when corrected for strain.

Professor Barry Sharpless of Scripps describes the Nobel-prizewinning development of titanium-based catalysts for stereoselective oxidation, the mechanism of their reactions, and their use in preparing esomeprazole. Conformational energy of cyclic alkanes illustrates the use of molecular mechanics.

Understanding conformational relationships makes it easy to draw idealized chair structures for cyclohexane and to visualize axial-equatorial interconversion. After quantitative consideration of the conformational energies of ethane, propane, and butane, cyclohexane is used to illustrate the utility of molecular mechanics as an alternative to quantum mechanics for estimating such energies. To give useful accuracy this empirical scheme requires thousands of arbitrary parameters.

Why ethane has a rotational barrier is still debatable. Analyzing conformational and configurational stereotopicity relationships among constitutionally equivalent groups reveals a subtle discrimination in enzyme reactions. When Baeyer suggested strain-induced reactivity due to distorting bond angles away from those in an ideal tetrahedron, he assumed that the cyclohexane ring is flat. He was soon corrected by clever Sachse, but Sachse's weakness in rhetoric led to a quarter-century of confusion.