CHEM 125a - Lecture 29 - Preparing Single Enantiomers and the Mechanism of Optical Rotation

Lecture 29 - Preparing Single Enantiomers and the Mechanism of Optical Rotation

Overview

Within a lecture on biological resolution, the synthesis of single enantiomers, and the naming and 3D visualization of omeprazole, Professor Laurence Barron of the University of Glasgow delivers a guest lecture on the subject of how chiral molecules rotate polarized light. Mixing wave functions by coordinated application of light's perpendicular electric and magnetic fields shifts electrons along a helix that can be right- or left-handed, but so many mixings are involved, and their magnitudes are so subtle, that predicting net optical rotation in practical cases is rarely simple.

Resources

Professor McBride's web resources for CHEM 125 (Fall 2008)

http://webspace.yale.edu/chem125_oyc/#L29

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Assignment

Reading assignments, problem sets, PowerPoint presentations, and other resources for this lecture can be accessed from Professor McBride's on-campus course website, which was developed for his Fall 2008 students. Please see Resources section below.

Course Media

Transcript

html

Audio

mp3

Low Bandwidth Video

mov [100MB]

High Bandwidth Video

mov [500MB]