CHEM 125a - Lecture 28 - Stereochemical Nomenclature; Racemization and Resolution
Lecture 28 - Stereochemical Nomenclature; Racemization and Resolution
Determination of the actual atomic arrangement in tartaric acid in 1949 motivated a change in stereochemical nomenclature from Fischer's 1891 genealogical convention (D, L) to the CIP scheme (R, S) based on conventional group priorities. Configurational isomers can be interconverted by racemization and epimerization. Pure enantiomers can be separated from racemic mixtures by resolution schemes based on selective crystallization of conglomerates or temporary formation of diastereomers.
Professor McBride's web resources for CHEM 125 (Fall 2008)
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