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CHEM 125a - Lecture 34 - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
Lecture 34 - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
Overview
Professor Barry Sharpless of Scripps describes the Nobel-prizewinning development of titanium-based catalysts for stereoselective oxidation, the mechanism of their reactions, and their use in preparing esomeprazole. Conformational energy of cyclic alkanes illustrates the use of molecular mechanics.
Resources
Professor McBride's web resources for CHEM 125 (Fall 2008)
http://webspace.yale.edu/chem125_oyc/#L34
This website may include third-party materials pertaining to relevant topics, provided for the user's convenience. Yale does not control or take responsibility for the content of any off-site pages or linked sites.
Assignment
Reading assignments, problem sets, PowerPoint presentations, and other resources for this lecture can be accessed from Professor McBride's on-campus course website, which was developed for his Fall 2008 students. Please see Resources section below.
Lecture Chapters
- Introduction for Professor Barry Sharpless [0]
- The Reactivity of Allyic Alcohols and Vanadium-Catalyzed Epoxidations [175]
- Research with Katsuki and the Discovery of Combining Titanium with Tartaric Acid [705]
- The Mechanism for Asymmetric Epoxidation of Olefins and the Story of Nexium [1271]
- The Conformation of Rings: Carvone and Cyclohexane [2466]
Lecture Chapters
- Introduction for Professor Barry Sharpless [0]
- The Reactivity of Allyic Alcohols and Vanadium-Catalyzed Epoxidations [175]
- Research with Katsuki and the Discovery of Combining Titanium with Tartaric Acid [705]
- The Mechanism for Asymmetric Epoxidation of Olefins and the Story of Nexium [1271]
- The Conformation of Rings: Carvone and Cyclohexane [2466]