CHEM 125a - Lecture 31 - Preparing Single Enantiomers and Conformational Energy

Lecture 31 - Preparing Single Enantiomers and Conformational Energy

Overview

After mentioning some legal implications of chirality, the discussion of configuration concludes using esomeprazole as an example of three general methods for producing single enantiomers. Conformational isomerism is more subtle because isomers differ only by rotation about single bonds, which requires careful physico-chemical consideration of energies and their relation to equilibrium and rate constants. Conformations have their own notation and nomenclature. Curiously, the barrier to rotation about the C-C bond of ethane was established by measuring its heat capacity.

Resources

Professor McBride's web resources for CHEM 125 (Fall 2008)

http://webspace.yale.edu/chem125_oyc/#L31

This website may include third-party materials pertaining to relevant topics, provided for the user's convenience. Yale does not control or take responsibility for the content of any off-site pages or linked sites.

Assignment

Reading assignments, problem sets, PowerPoint presentations, and other resources for this lecture can be accessed from Professor McBride's on-campus course website, which was developed for his Fall 2008 students. Please see Resources section below.

Course Media

Transcript

html

Audio

mp3

Low Bandwidth Video

mov [100MB]

High Bandwidth Video

mov [500MB]